Although sport-related concussion or mild traumatic brain injury are common, they are infrequently associated with posttraumatic stress disorder (PTSD). This report describes the case of a 17-year-old male high school football player who sustained a sport-related concussion complicated by the development of PTSD. The association between PTSD and mild traumatic brain injury is briefly reviewed. The diagnosis and resolution of his PTSD symptoms in response to the treatment with the antidepressant vortioxetine and its mechanism of action are summarized.
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